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Choosing Your Statin: A Closer Look at Side Effects

Written and medically reviewed by Dorcas Morak, Pharm.D

Updated on August 22nd, 2023

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Statins, the go-to prescription drugs for lowering cholesterol, play a vital role in maintaining our overall heart health. With cholesterol being a fatty substance that's essential for cell and organ function, an excessive amount can lead to cardiovascular risks. Since a vast majority of adults in the US who are on cholesterol-lowering medication opt for statins, it's worth understanding the potential side effects and finding out which ones carry fewer.

The Role of Statins: More than Just Pills

Let's appreciate the 'why' behind statins. High cholesterol levels can lead to atherosclerosis, where cholesterol accumulates within the blood vessel walls and narrows them down, restricting blood flow to the heart. This situation can trigger heart attacks. Hence, the role of statins becomes indispensable.

Not All Cholesterol is Bad

Cholesterol can be either low-density lipoprotein (LDL), the notorious 'bad' cholesterol, or high-density lipoprotein (HDL), the 'good' cholesterol. Having too much LDL or too little HDL increases the risk of heart disease, stroke, and other serious health problems.

The Magic of Statins: Guarding Against Heart Disease

Statins block a substance in your liver that's required to make cholesterol, effectively lowering your blood cholesterol levels. Common statins include simvastatin (Zocor), atorvastatin (Lipitor), pravastatin (Pravachol), rosuvastatin (Crestor), fluvastatin (Lescol), and lovastatin (Altoprev).

The Downside: Statin Side Effects

Despite their widespread usage and proven efficacy, statins can still cause certain side effects like muscle aches, potential liver damage, and an increased risk of developing type 2 diabetes.

Who Should Be Cautious?

Certain people are more likely to experience statin side effects, including those on other cholesterol-lowering meds, individuals above 80, women, people with smaller body frames, those with kidney or liver diseases, heavy drinkers, people on certain other medications, and those with conditions like hypothyroidism.

Choosing the Safest Statin

While statins are largely safe, research suggests that simvastatin (Zocor) and pravastatin (Pravachol) are typically better tolerated.

Safest Statin for the Liver?

Low-dose statins like atorvastatin (Lipitor) are often deemed safe for individuals with mild liver enzyme abnormalities. However, for those with moderate to severe liver disease, safety hasn't been definitively established, and regular liver function tests are advised.

Which Statin Comes with Less Muscle Pain?

Lipophilic statins like atorvastatin (Lipitor), simvastatin (Zocor), and fluvastatin (Lescol) can diffuse into muscles more readily, possibly causing more aches. On the other hand, hydrophilic statins such as pravastatin (Pravachol) and rosuvastatin (Crestor) are generally associated with fewer muscle aches. Remember, statins are serious meds and you should always chat with your healthcare provider before starting or altering your regimen. If cost is a concern, consider using an RxLess discount coupon to ease the expenses at pharmacies like CVS, Rite Aid, and Walgreens.

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