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Zepbound: A New Dawn in Obesity Treatment by Eli Lilly

Written and medically reviewed by Dorcas Morak, Pharm.D

Updated on December 14th, 2023

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Big news in the world of healthcare: Eli Lilly's Zepbound (tirzepatide) injection has received the FDA's stamp of approval, marking a revolutionary step in treating obesity and weight-related health issues. Let's dive into what makes Zepbound a game-changer in chronic weight management.

Zepbound: A Unique Player in Obesity Treatment

What makes Zepbound stand out? It's the first of its kind to activate both GIP (glucose-dependent insulinotropic polypeptide) and GLP-1 (glucagon-like peptide-1) hormone receptors. This dual-action approach positions Zepbound as a powerful ally for adults grappling with obesity or weight issues, along with related health problems.

Who's in Line for Zepbound?

Zepbound is here for adults with a BMI of 30 kg/m2 or more (that's obesity) or a BMI of 27 kg/m2 or more (overweight) with complications like high blood pressure, high cholesterol, type 2 diabetes, obstructive sleep apnea, or heart disease. The key is combining Zepbound with a diet lower in calories and more physical activity.

The Science Behind Zepbound's Success

The FDA's thumbs-up is backed by impressive results from the phase 3 SURMOUNT-1 and SURMOUNT-2 trials. In SURMOUNT-1, participants using Zepbound alongside diet and exercise saw significant weight loss – the highest dose led to an average loss of 48 pounds. That's a ray of hope for those tackling obesity.

Using Zepbound: What to Expect and Side Effects

While Zepbound can be a big help, it may come with some gastrointestinal side effects like nausea, diarrhea, and vomiting. These usually lessen over time. However, it's worth noting that Zepbound hasn't been tested in people with a history of pancreatitis or severe gastrointestinal issues.

Cost and Availability of Zepbound

Zepbound is expected to hit the U.S. market in six doses by year's end. It's priced at $1,059.87, but don't let that number scare you. Lilly is rolling out a savings card program to make it more accessible. With insurance, you could pay as little as $25 for a one or three-month prescription. Without insurance, a one-month prescription might cost around $550. However, the RxLess app can be a game-changer in managing the cost of medications like Zepbound. RxLess offers access to discounts and the most accurate, real-time price on various medications, potentially providing further cost savings on Zepbound prescriptions, whether you're insured or not. Checking the app each time you head to the pharmacy will ensure you get the best price available and that you’ll always know your cost before you pick up your prescription.

Zepbound's Global Prospects

Zepbound's active ingredient, tirzepatide, is under review for weight management in Europe, China, the UK, and other markets. If it gets the green light globally, it could truly transform obesity treatment worldwide.

So, there you have it! Zepbound is stepping onto the scene as a significant advancement in fighting obesity. It's bringing new hope and options for those facing this challenging condition. Keep an eye out for its arrival and read our guide about existing treatments to stay informed about your options for weight loss medications. Here's to a healthier future!

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