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Generic: Omeprazole Brand: Prilosec OMEPRAZOLE (oh ME pray zol) prevents the production of acid in the stomach. It is used to treat gastroesophageal reflux disease (GERD), ulcers, certain bacteria in the stomach, inflammation of the esophagus, and Zollinger-Ellison Syndrome. It is also used to treat other conditions that cause too much stomach acid.