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Generic: Fluocinolone, Hydroquinone, Tretinoin Brand: Tri-Luma FLUOCINOLONE; HYDROQUINONE; TRETINOIN (floo oh SIN oh lone; hye droe KWIN ohn; TRET i noe in) is a combination of a corticosteroid, a retinoid similar to vitamin A, and a drug used to lighten the skin. It is used on the skin to treat melasma. Melasma is a condition that causes dark spots on the face, especially the cheeks and forehead.

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