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Generic: Antithrombin III (Human) Brand: Thrombate III ANTITHROMBIN III (AN te throm bin) is a natural protein. It is used to treat patients with low levels of antithrombin III. People with this condition may have an increased risk for developing blood clots, especially during surgery or during pregnancy. This medicine may help to reduce the risk for blood clots or help to treat blood clots once they have already developed.