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What is pamidronate?
Hypercalcemia of Malignancy Pamidronate disodium, in conjunction with adequate hydration, is indicated for the treatment of moderate or severe hypercalcemia associated with malignancy, with or without bone metastases. Patients who have either epidermoid or non-epidermoid tumors respond to treatment with pamidronate disodium. Vigorous saline hydration, an integral part of hypercalcemia therapy, sho...uld be initiated promptly and an attempt should be made to restore the urine output to about 2 L/day throughout treatment. Mild or asymptomatic hypercalcemia may be treated with conservative measures (i.e., saline hydration, with or without loop diuretics). Patients should be hydrated adequately throughout the treatment, but overhydration, especially in those patients who have cardiac failure, must be avoided. Diuretic therapy should not be employed prior to correction of hypovolemia. The safety and efficacy of pamidronate disodium in the treatment of hypercalcemia associated with hyperparathyroidism or with other non-tumor-related conditions has not been established. Paget’s Disease Pamidronate disodium is indicated for the treatment of patients with moderate to severe Paget’s disease of bone. The effectiveness of pamidronate disodium was demonstrated primarily in patients with serum alkaline phosphatase ≥3 times the upper limit of normal. Pamidronate disodium therapy in patients with Paget’s disease has been effective in reducing serum alkaline phosphatase and urinary hydroxyproline levels by ≥50% in at least 50% of patients, and by ≥30% in at least 80% of patients. Pamidronate disodium therapy has also been effective in reducing these biochemical markers in patients with Paget’s disease who failed to respond, or no longer responded to other treatments. Osteolytic Bone Metastases of Breast Cancer and Osteolytic Lesions of Multiple Myeloma Pamidronate disodium is indicated, in conjunction with standard antineoplastic therapy, for the treatment of osteolytic bone metastases of breast cancer and osteolytic lesions of multiple myeloma. The pamidronate disodium treatment effect appeared to be smaller in the study of breast cancer patients receiving hormonal therapy than in the study of those receiving chemotherapy, however, overall evidence of clinical benefit has been demonstrated (see CLINICAL PHARMACOLOGY, Osteolytic Bone Metastases of Breast Cancer and Osteolytic Lesions of Multiple Myeloma, Clinical Trials section).
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Fill a 90-Day Supply to Save
In some cases, filling your prescription for a 90-day supply will give you a lower total cost compared to filling the same prescription multiple times for smaller amounts. Even if the drug and the dosage are the same, you will need a brand new prescription from your doctor to switch to 90-day fills.
Your pharmacy cannot transfer a prescription for a 30-day supply into one with a 90-day supply. Also, some insurance plans may require that you use a mail order pharmacy for prescriptions greater than a 30-day supply.
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Many programs are available from government organizations, non-profits, and drug manufacturers to assist with the costs of medications. It’s free to sign up for these programs if you meet their requirements for eligibility. The enrollment options are different for each program, but they can usually be completed on- line, over the phone, or with the help of your doctor’s office.
Please note, patient assistance programs cannot be used in conjunction with these RxLess offers. Many times however, the offers listed on RxLess will be less expensive than manufacturer coupons, copay cards, or patient assistance programs – so make sure you compare all options before making a purchase.
Research Lower Cost Alternatives
There may be other prescriptions that work equally well at treating a condition, but that are available at different prices. Ask your doctor if there are any lower cost alternative drugs that - and if switching to a different drug could affect your treatment. To get started, check the section below for other drugs related to pamidronate.
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Bone Resorption Inhibitors - Drugs used to treat postmenopausal and glucocorticoid induced osteoporosis, Paget's disease of the bone and malignant hypercalcemi