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INSULIN LISPRO; INSULIN LISPRO PROTAMINE (IN su lin LYE sproe; IN su lin LYE sproe PRO ta meen) is a human-made form of insulin. This drug lowers the amount of sugar in your blood. This medicine is a mixture of a rapid-acting insulin and a longer-acting insulin. It starts working quickly after injection and continues to work for as long as 12 to 24 hours.