Written and medically reviewed by Dorcas Morak, Pharm.D
When it comes to managing mental health conditions like depression and anxiety, selective serotonin reuptake inhibitors (SSRIs) such as Prozac (fluoxetine) and Zoloft (sertraline) are commonly prescribed. Both medications work by influencing serotonin levels in the brain, thereby improving mood, appetite, energy levels, and sleep and reducing anxiety and compulsive behaviors. While Prozac and Zoloft share many similarities, they also have distinct differences that can affect their suitability for different patients.
What are the Indications of Prozac and Zoloft?
Prozac and Zoloft are both approved for treating major depression, obsessive-compulsive disorder (OCD), and panic disorder. However, they each have unique approvals for other conditions. Prozac is approved to treat bulimia nervosa and premenstrual dysphoric disorder (PMDD), while Zoloft is approved for post-traumatic stress disorder (PTSD) and social anxiety disorder or social phobia.
Who can Use Prozac and Zoloft?
One key difference between Prozac and Zoloft is their approved age groups. Prozac is the only SSRI approved by the FDA to treat depression in children as young as eight. It is also approved to treat OCD in children as young as 8 whereas Zoloft is approved for treating OCD in children six and older; its other uses are only approved for adults. This distinction is crucial for pediatric treatment planning.
What are the Available Formulations for Zoloft and Prozac?
Prozac and Zoloft come in different forms and dosages, allowing flexibility for patient compliance and preference. The brand Prozac is available in oral capsules (10 mg, 20 mg, 40 mg, and 90 mg), whereas its generic Fluoxetine is available in capsules (10 mg, 20 mg, 40 mg and 90 mg), tablets (10 mg, 20 mg, and 60 mg), and an oral liquid concentrate (20 mg/mL).
The brand Zoloft is available in tablets (25 mg, 50 mg, and 100 mg) and an oral liquid concentrate (20 mg/mL). The liquid form of Zoloft is helpful for patients who have difficulty swallowing pills. The generic Sertraline is available in tablets (25 mg, 50 mg, and 100 mg), capsules (150 mg and 200 mg), and an oral liquid concentrate (20 mg/mL).
What are the Side Effects of Prozac and Zoloft?
Prozac and Zoloft both have potential side effects, including nausea, vomiting, diarrhea, nervousness, dizziness, sexual problems, and insomnia. Zoloft is more likely to cause diarrhea, while Prozac is more likely to cause dry mouth and sleep problems. Neither drug usually causes drowsiness, and both are less likely to cause weight gain compared to older antidepressants.
Are there Serious Side Effects with Prozac and Zoloft?
Both Prozac and Zoloft can lead to serious side effects, including suicidal thoughts in children, teenagers, and young adults. This risk highlights the need for close monitoring by healthcare providers when prescribing these medications to younger people.
How Much do Prozac and Zoloft Cost?
Both are available as generics, which are significantly cheaper than brand-name versions. A 30-day supply of Prozac is about $100 more expensive than Zoloft. A 30-day supply of sertraline 50 mg will cost approximately $10, while a 30-day supply of fluoxetine 20 mg will cost about $9 will RxLess, depending on the pharmacy. For the most accurate and current discounts, join the RxLess® Assurance Plan by downloading our free app.
