Written and medically reviewed by Dorcas Morak, Pharm.D
When it comes to managing pain, inflammation, or fever, two over-the-counter (OTC) medications are often at the forefront of consideration: Naproxen (Aleve) and Ibuprofen (Advil). Both belong to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs) and are widely used for their effectiveness. But which one should you choose? Let's delve into the specifics to help you make an informed decision.
What are the Uses of Naproxen and Ibuprofen?
Naproxen (Aleve) and Ibuprofen (Advil) are highly effective for treating pain and inflammation. They work similarly in the body to reduce pain and swelling, making them suitable for various conditions such as muscle aches, joint pain, headaches, menstrual cramps, and more.
Is Ibuprofen or Naproxen More Effective for Acute and Chronic Pain?
Research shows no significant difference in the effectiveness of naproxen and ibuprofen for acute and chronic pain relief. Both work well compared to a placebo, with neither being superior. Therefore, the choice often depends on factors like duration of action, side effects, and personal preference.
Which NSAID, Ibuprofen or Naproxen, has a Longer Duration of Action?
Naproxen (Aleve) lasts up to 12 hours, making it more convenient with just two daily doses. An extended-release version lasts even longer and is available by prescription. In contrast, Ibuprofen (Advil) is short-acting and needs to be taken every 4 to 6 hours, which can be less convenient.
Which NSAID, Ibuprofen or Naproxen, has better Gastrointestinal Safety?
NSAIDs, including Naproxen (Aleve) and Ibuprofen (Advil), can cause GI issues like ulcers and bleeding. Ibuprofen (Advil) carries a slightly lower risk than naproxen, but all NSAIDs can be problematic if not used correctly. Long-term users may benefit from pairing NSAIDs with a proton pump inhibitor (PPI) such as Omeprazole (Prilosec) to safeguard the stomach. Combination medications like Vimovo, which includes naproxen and esomeprazole, are also available to reduce GI risks.
Does Naproxen or Ibuprofen Cause Cardiovascular Problems?
All NSAIDs, including Naproxen (Aleve) and Ibuprofen (Advil), can increase the risk of heart attack or stroke at high doses or over prolonged use. Naproxen (Aleve) may potentially carry a lower cardiovascular risk compared to other NSAIDs, particularly at doses up to 500 mg twice daily. However, further research is necessary to confirm these findings conclusively.
Which NSAID, Ibuprofen, or Naproxen Should Children Use?
Ibuprofen (Advil) is frequently chosen to treat pain and inflammation in children. It's approved for use in children as young as three months old and comes in liquid and chewable forms, which are easier for young children to take. Naproxen (Aleve), however, is less commonly used in children under 12 years old, although pediatricians may prescribe it in specific situations.
What are the Available Strength of Naproxen?
Over-the-counter Naproxen (Aleve) comes in 220 mg tablets or capsules, recommended for use every 8 to 12 hours. Prescription naproxen is higher, between 250mg to 550 mg tablets typically taken twice daily. There's also a liquid form for those who find pills hard to swallow.
What are the Available Strength of Ibuprofen?
Over-the-counter Ibuprofen (Advil) is available in 100 mg or 200 mg tablets, typically 200 mg every 4 to 6 hours. Prescription ibuprofen comes in higher doses like 400 mg, 600 mg, or 800 mg tablets, with a maximum daily dose of 3,200 mg. Always make sure to not exceed the maximum daily dosage.
Which Pain Reliever, Ibuprofen or Naproxen, Should You Choose?
If you need extended pain relief and prefer fewer daily doses, Naproxen (Aleve) may be the better option. It may also be a better choice if you have cardiovascular issues, but always remember to consult your healthcare provider. If you are concerned about GI side effects however or need medication for a child, Ibuprofen (Advil) could be more suitable.
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