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Lisinopril vs. Amlodipine: Exploring Blood Pressure Medication Differences

Updated on June 19th, 2024

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Written and medically reviewed by Dorcas Morak, Pharm.D

Millions of Americans suffer from high blood pressure, which significantly increases the risk of heart attacks and strokes. Managing this condition often involves medication, with Lisinopril and Amlodipine being two popular options. Each drug works in its own way and comes with distinct side effects and considerations. We will delve into their differences to assist you in making an informed choice

How Do Lisinopril and Amlodipine Work?

Lisinopril (Zestril), an ACE inhibitor, blocks the conversion of angiotensin I to the powerful vasoconstrictor angiotensin II. This action relaxes blood vessels, effectively lowering blood pressure. While Amlodipine (Norvasc), a calcium channel blocker, prevents calcium ions from entering vascular smooth muscle and heart cells. This leads to vasodilation and reduces peripheral resistance, lowering blood pressure.

How do the Lisinopril and Amlodipine Differ in Uses and Side Effects?

Lisinopril (Zestril) effectively manages hypertension and heart failure and improves survival after a heart attack. However, a common side effect is a persistent dry cough. Amlodipine (Norvasc) is indicated for hypertension and angina but can cause peripheral edema, leading to fluid retention in the lower legs.

What are the Available Dosage Options for Lisinopril and Amlodipine?

Lisinopril is available in oral tablet form under brand names like Qbrelis, and Zestril. Its dosages range from 2.5 mg to 40 mg and are tailored to your specific needs. Amlodipine, taken orally as tablets, is available under the brand names Norvasc and Norliqva. Its typical dosages range from 2.5 mg to 10 mg and are adjusted based on your response.

Which Lasts Longer: Lisinopril or Amlodipine?

Lisinopril (Zestril) is effective for approximately 16.4 hours, usually taken once a day for best results. Amlodipine (Norvasc), on the other hand, lasts much longer- around 35 hours, allowing for less frequent dosing. While both are typically taken once daily, Amlodipine has a longer duration of action than Lisinopril.

What Are the Possible Food and Disease Interactions with Amlodipine and Lisinopril?

Lisinopril (Zestril) and Amlodipine (Norvasc) can interact with certain foods and underlying medical conditions. For example, alcohol can enhance their blood pressure-lowering effects, risking hypotension. People with conditions like angioedema or renal dysfunction may experience worsened symptoms or altered responses to these medications. Therefore, healthcare providers must consider these interactions when planning treatment.

Are Amlodipine or Lisinopril Safe During Pregnancy?

Lisinopril (Zestril) is classified as Pregnancy Category D, showing clear evidence of risk. Amlodipine (Norvasc) is Pregnancy Category C, meaning the risk can't be ruled out. Pregnant individuals must consult their healthcare professionals to determine the safest treatment options.

Which is More Cost-Effective: Amlodipine or Lisinopril?

Lisinopril (Zestril) is the more affordable option. A 30-tablet supply of Lisinopril (20 mg) retails for about $16, and the same supply of Amlodipine (10 mg) retails for approximately $27. RxLess offers discounts for both these medications, you can get Lisinopril for as low as $3 and Amlodipine for $7, an 81% and 74% saving.

Looking for the most accurate discounts on-the-go? Join the RxLess Assurance Plan by downloading our free app. You will spend less time worried about budgeting for prescriptions and know what you’ll pay at the counter. Every time.

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