Written and medically reviewed by Dorcas Morak, Pharm.D
Zepbound (tirzepatide) and Wegovy (semaglutide) are breakthrough medications in the field of weight management. Both belong to a class of drugs known as GLP-1 receptor agonists, designed to help individuals manage their weight effectively. Recent studies suggest that Zepbound may lead to more significant weight loss compared to Wegovy, prompting a closer look at the effectiveness, mechanisms of action, and broader roles of these medications in a comprehensive weight management plan.
What is Zepbound (Tirzepatide)?
Zepbound is a dual agonist that mimics the action of two hormones: GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). This unique mechanism helps reduce appetite and improves the body's ability to metabolize sugars and fats, leading to more substantial weight loss. Zepbound received approval for weight management in late 2023.
What is Wegovy (Semaglutide)?
Wegovy, which was approved in 2021, was the first new weight-loss medication introduced in almost a decade. It works by acting as a GLP-1 agonist, mimicking a natural gut hormone that helps regulate appetite, reducing hunger, and increasing the sensation of fullness.
Is Zepbound More Effective for Weight Loss than Wegovy?
A recent study published in JAMA Internal Medicine analyzed the electronic health records of more than 41,000 adults and found that Zepbound resulted in more significant weight loss compared to Wegovy. Patients on the highest dose of Zepbound lost approximately 21% of their body weight over 72 weeks, while Wegovy users lost about 15% after 68 weeks. This data suggests Zepbound may offer a more effective option for those seeking greater weight loss.
Does Zepbound Promote Faster Weight Loss than Wegovy?
The study also highlighted that Zepbound led to quicker weight loss than Wegovy . After three months, Zepbound users lost an average of 5.9% of their body weight, compared to 3.6% for Wegovy users. At six months, Zepbound users achieved a 10.1% weight loss, while Wegovy users lost 5.8%. By 12 months, Zepbound users had lost an average of 15.3% of their body weight, compared to 8.3% for Wegovy users. These findings underscore Zepbound's potential for more rapid and substantial weight loss.
Are Zepbound and Wegovy Safe?
Both medications have similar safety profiles, with no significant differences in terms of serious side effects. Common side effects for both include nausea and vomiting, which tend to subside as the body adjusts to the medication. However, individual responses to these medications can vary, depending on personal health goals and tolerance levels.
Key Differences Between Zepbound and Wegovy
While both Zepbound and Wegovy are effective weight-loss medications, there are some notable differences that may influence the choice between them:
1. Mechanism of Action: Zepbound targets both GLP-1 and GIP receptors, potentially enhancing weight loss more effectively than Wegovy, which only targets GLP-1. 2. Dosage Schedule: Zepbound starts at a higher dose (2.5 mg) compared to Wegovy (0.25 mg), allowing for quicker dose optimization and potentially faster results. 3. Additional Health Benefits: Wegovy has demonstrated benefits in reducing cardiovascular risk, making it a suitable choice for patients with heart disease. Zepbound is currently being studied for additional benefits in conditions like obstructive sleep apnea. 4. Approval for Adolescents: Wegovy is approved for use in adolescents aged 12 and older, while Zepbound is only approved for adults.
Cost and Insurance Coverage
Cost is an important consideration when choosing between Zepbound and Wegovy .. Both medications can be expensive without insurance coverage. However, Zepbound vials have recently become more affordable, thanks to the savings programs available through RxLess Assurance Plan. This plan offers significant discounts, making Zepbound vials up to 60% less expensive than the pen injector form for a one-month supply. The RxLess Assurance Plan provides patients with access to lower-priced medications, regardless of their insurance status, making weight-loss treatments more accessible.
Becoming a member of the RxLess Assurance Plan is simple—all you have to do is download the free mobile app. Once enrolled, you can easily access savings on Zepbound and other medications.
Patients should consult with their healthcare provider and insurance company to determine their coverage options for these medications. Many insurance plans are starting to cover Zepbound, which may help reduce out-of-pocket costs for eligible patients. Exploring the RxLess Assurance Plan can offer additional savings for those paying out of pocket or whose insurance coverage is limited.
