Written and medically reviewed by Dorcas Morak, Pharm.D
Antihistamines, best known for tackling allergies, can also make you drowsy, making them useful as sleep aids. Two popular choices, Hydroxyzine (Vistaril) and Benadryl, are often considered for managing sleep issues. We will compare Hydroxyzine (Vistaril) and Benadryl and explore whether antihistamines are safe for treating chronic insomnia and other sleep disorders. Read on to discover how these antihistamines can help you sleep better.
Are Hydroxyzine and Benadryl the Same?
Hydroxyzine (Vistaril) and Benadryl are similar antihistamines but have unique properties and uses. Hydroxyzine (Vistaril), a prescription antihistamine, treats itching, hives, and anxiety disorders by lowering histamine levels, which peak during the day. Thus, it promotes sedation. It also affects serotonin, adding to its calming effects and making it useful for anxiety and sleep problems. Benadryl, a brand of diphenhydramine, is an over-the-counter antihistamine used for allergy relief, motion sickness, and Parkinson's symptoms. Its strong sedative effects make it a go-to for insomnia and sleep issues.
Can Hydroxyzine Be Used as a Sleep Aid?
Hydroxyzine, sold as Atarax (hydroxyzine hydrochloride) and Vistaril (hydroxyzine pamoate), differs only in its salt form. Vistaril is often preferred for sleep and anxiety, but Hydroxyzine may not be ideal for older people due to side effects like increased fall risk. Using Hydroxyzine for insomnia requires a prescription. Avoid self-medicating and consult a healthcare provider to weigh its pros and cons as a sleep aid.
Can Benadryl Be Used as a Sleep Aid?
Yes, Benadryl (diphenhydramine) can be used as a sleep aid due to its sedative properties. However, it is generally not recommended for long-term use because it can cause tolerance, dependence, and side effects like dry mouth, dizziness, and confusion, especially in older adults. Always consult a healthcare professional before using Benadryl or any medication for sleep.
Which is Better - Benadryl or Hydroxyzine?
Both are generally safe and effective, but the best choice depends on your health and other medications you may be using. Your doctor might also refer you to a sleep specialist to check for underlying sleep issues like obstructive sleep apnea or circadian rhythm disorders. Therefore, choosing between Hydroxyzine (Vistaril) and Benadryl requires consulting your healthcare provider.
Which Antihistamine is Best for Sleep?
Benadryl might be more suitable than other antihistamines for allergies and drowsiness. Another popular over-the-counter sleep aid is Doxylamine Succinate (Unisom SleepTabs). Some prescription medications like Trazodone, Amitriptyline, and Gabapentin (Neurontin) are also used off-label for insomnia. Depending on the cause of your insomnia, your doctor might recommend these or suggest non-medication options like cognitive-behavioral therapy (CBT) and good sleep hygiene.
What are the Side Effects of Benadryl and Hydroxyzine?
Hydroxyzine (Vistaril) and Benadryl are both sleep aids due to their drowsiness effects, but they have some other side effects. They can cause dry mouth, blurred vision, and urinary retention. Benadryl may also enlarge the prostate and affect heart rhythm, while Hydroxyzine can lead to restless muscle movement and seizures. Benadryl is over-the-counter, but you will need a prescription for Hydroxyzine.
Who Should Not Use Antihistamine as a Sleep Aid?
It is crucial to consult a healthcare provider before taking antihistamines for sleep, especially for those with certain medical conditions, pregnant or breastfeeding women, and older adults. You must also avoid alcohol while on these due to potentially severe side effects.
How Much do Benadryl and Hydroxyzine Cost?
Both are available as generics, which are cheaper than brand-name versions. A 30-day supply of Hydroxyzine 25 mg will cost approximately $8, while a 30-day supply of Benadryl 25 mg will cost about $2.50 with RxLess, depending on the pharmacy. For the most accurate and current discounts, join the RxLess Assurance Plan by downloading our free app.
